DND/TTRPG Homebrew or published setting? Or a mix of both?

[Ra McBirdface]

I am a Gm of five years for mostly dnd 5e and i was wondering if anyone who also engages in worldbuilding/running games if you rather use published settings or use your own.
I mix and match what i like and created a somwhat balanced universe that both takes stuff from published stuff and homebrew stuff. I mainly made it for DnD 5e with Spelljammer and Historica Arcanum in mind but it has lore elements from World of Darkness, Cthulhu Mythos and other stuff.

Tell me about yours please.